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Can Cannabis Cause Schizophrenia?

Cannabis Marijuana Skunk schizophrenia psychosis addiction

If you logged in to the front page of The Huffington Post today you might have seen an article by Rupert Wolfe Murray called Can Cannabis make you Crazy? Rupert asked his readers to consider the other side of the legalisation argument, not the one that is advocated by Richard Branson.

On the same day that this was published BBC Radio 4’s Life Scientific interviewed psychiatrist Professor Sir Robin Murray MD DSc FRCP FRCPsych FMedSci FRS about his life's work - studying schizophrenia (psychosis) and trying to understand why some people have schizophrenia and others don't. He gave a valuable insight into the potential effects of cannabis on mental health.

Dr. Murray says psychosis means you don't have the ability to “filter out stimuli” and this makes everything significant to the person with the condition. “Why are these people wearing red jumpers? Could it be that somebody has hired them to follow me?” This is caused by the dopamine levels in the brain being too high which gives everything significance and gives the person a feeling of great importance... perhaps they believe they have been chosen by God for a particular mission, or “could it be that all these things are happening to me because they’re against me and they’re all out to get me?” These are grandiose illusions and paranoid illusions.

Social causes of schizophrenia 

Murray found out that psychosis is not just a brain disease - living in a city significantly increases the risk of schizophrenia (the bigger the city, the greater the risk) and migrants are six times more likely to develop the condition than long term residents. This suggests that the problem has social causes, as well as biological.

He's also outspoken about the mental health risks of smoking cannabis, based both on his scientific research and direct experience working at the Maudsley Hospital in South London.

Dr. Murray reports seeing psychosis in patients who had not shown any developmental difficulties and who did well in their youth. They didn’t fit the usual model of the person that develops psychosis. “Since about 2002 it’s become apparent that smoking cannabis, and certainly the more modern variants of cannabis increases your risk, there are a number of causal risk factors that act together to push people  over the threshold into psychosis, it’s clear that drug abuse is one of these.”

More potent strains of cannabis

Murray points out that all studies that have been published, with one exception, have investigated the effects of THC in more old-fashioned forms of cannabis such as resin, which contains about 4-5% THC, but modern-day skunk contains about 14-18% THC. He believes that smoking 4 or 5 joints a day for five years at this potency will “certainly increase your risk of psychosis”.

“The evidence seems to be that if you’re smoking skunk every day then the risk goes up probably about 6-fold.”  

He points out that drug abuse is among a number of risk factors for psychosis and that you would have to have a predisposition towards psychosis in order for it to be triggered.

Advice

If you think you might be addicted to cannabis we recommend that you consult with your G.P and visit Narcotics Anonymous online. This self-help group is similar to Alcoholics Anonymous but has a focus on drug addiction. Your local Narcotics Anonymous groups can offer immediate help and support.

If you want to immerse yourself in an intensive treatment programme then residential rehab could be the right choice for you. You can email or call us to speak to someone about your addiction before you commit to any treatment.

If you are worried that you or a family member may be developing schizophrenia then we recommend that you visit your G.P as soon as possible. You can also find lots of information at Mind, a mental health charity.

17 comments

wolfemurray

Fascinating article and I'm glad you wrote this summary as I didn't here the radio programme

I got a lot of nasty comments from pro-cannabis people on my article in Huffington Post, but a Harley St therapist contacted me and said "I agree with you". I checked out her recent article on cannabis and mental illness and found this excellent reference: : http://www.myspace.com/sarahgraham69/blog/502794499

Here is a relevant extract:

"Of all the mind-altering drugs that people use cannabis is the one that causes the most controversy and about which there is enormous cultural denial.

My appearances on TV talking about cannabis (see www.youtube.com/sarahgdirects) often bring me considerable hate mail from people who think that cannabis is "just a bit of spliff".

Victoria McCann

Thanks for your comment Rupert, there's a good piece here by Peter Hitchens in the Daily Mail called 'The Cannabis Cult' - you might identify with him! He believes people are guided to these sites/articles to post abusive messages. http://hitchensblog.mailonsunday.co.uk/2012/01/the-cannabis-cult.html#co...

Jason Reed

Hi Rupert and Victoria,

I just wanted to drop a quick note to explain why I wrote a reply on the HuffPo to Mr Wolfe-Murray:

http://www.huffingtonpost.co.uk/jason-reed/cannabis-does-not-drive-you-c...

I've tried to cover a lot of areas in this, but inevitably some aspects had to take an edit. As said, I wrote in good faith and tried to keep it out of the realms of personal rebuttal. I hope that comes across.

I would like to address, what you say: "I got a lot of nasty comments from pro-cannabis people..." -- you do tend to find that addressing cannabis will get a response as it is an area that a person's liberty is at stake.

I think one of the reasons that the piece received a fair bit of negative feedback is owing to the lack of science in the piece in favour of opinion. It's also a full misconception that those that comment are 'pro cannabis' simply by default. To re-state, there are many many scientist & academics that take exception to bad science and will really take us to task if we get it wrong. I tend to speak direct to the primary sourcers.

As most scientist will tell you, some of the science around drugs is some of the worst around, especially tabloid science which is laughable on many levels. It's quite actionable. I will only cite from peer reviewed or eminent figures, and will avoid my personal voice when addressing drug sciences -- or any science. You have to remember that drug policy, and the related subject, is trying to find a solid footing based on science and evidence, and I'm sure we can all agree this is preferable.

The Sir Robin Murray programme is certainly interesting, and as you can see, he freely admits himself that the caveats involved in the cannabis psychosis link are quite vast and significant -- not to mention he conveys that the risks are still significantly small, but of course worth the investigations. It's also hugely relevant that migrants are 6 times more likely to suffer than indigenous folk, and city living is a major contributing factor. It's quite apparent that this discussion is a vast tapestry, and addressing the whole subject is preferable.

Thank you for allowing me to address you and with my sincere best,

Jason.

wolfemurray

Thanks for the comment Jason, and I appreciate your objective tone. I am not a scientist or a therapist so I was just writing about what I had picked up from various sources in the treatment business over the years.

Peter Reynolds

To echo Jason, the reason your piece was demolished is because it is a house of cards built on sand.

The "drug support industry" is one of the most wicked and corrupting influences in modern society. Entirely for its own benefit it invents quasi-medical conditions and conspires with the police, the CPS and the courts to drum up business for itself.

The best evidence about cannabis and mental health is:

1. Hickman et al, 2009. A review of all published research so, by definition­, not cherry picked. It shows that the risk of lifetime cannabis use correlatin­g with a single diagnosis of psychosis is at worst 0.013% and probably less than 0.003%.

2. Hospital Episode Statistics. Count of finished admission episodes (FAE) with a primary diagnosis of mental and behavioural disorders due to use of cannabinoids (ICD10 code F12) and alcohol (ICD10 code F10)

Cannabinoids (F12)

2009-10 713
2010-11 799

Alcohol (F10)

2009-10 47,402
2010-11 47,287

Source: Hospital Episode Statistics (HES), The NHS Information Centre for health and social care.

There are three million regular users of cannabis (Atha et al 2011) and 31 million regular users of alcohol (NHS Information Centre 2009). Therefore alcohol use is six times more likely to result in admission for mental and behavioural disorders.

3. Frisher et al 2009. The ACMD commissioned a study by Keele University into the trends in schizophrenia specifically to test the claims in the media of a link between it and cannabis. It looked at almost 600,000 patients and concluded that "..the incidence and prevalence of schizophrenia and psychoses were either stable or declining" despite alleged increased use of allegedly more potent cannabis.

wolfemurray

I would like to know how you can justify the claim: 'the "drug support industry" is one of the most wicked and corrupting influences in modern society.'

From what I have seen of residential rehab work they successfully treat people in the grip of addictions. There are thousands of people who owe their lives to residential rehab treatment.

You say the rehab business "conspires with the police, the CPS and the courts to drum up business for itself." It would be interesting to know if you can point to any cases of these sources referring any serious numbers of people into treatment.

Sara-L

Peter Reynolds I see that you are in the pockets of big pharma... that must pay nicely... a good incentive to trawl the net and barrage people over matters which don't suit your business interests http://www.campaign.mondialvillage.com/

It says:
Peter Reynolds, leader of CLEAR, has brought the UK cannabis campaign into disrepute on many levels - the most serious types of disrepute being:
1) his racist, homophobic, anti-gay and anti-Semite opinions which he has published on his blog, which he has now removed, and all of which same mentioned articles this campaign has preserved copies.
2) his verbal abuse and exclusion towards both members of CLEAR and members of the public in general.
3) his attempts to change the provenance of the UK political party CLEAR
4) his unsubstantiated statements concerning cannabis sentencing laws in the United Kingdom amongst other subject topics.
5) his unconvincing statements concerning his campaigning background and history within the UK cannabis campaign.

Cannabis for Autism

When you appear to be in the business of 'medicine prevention', expect a bit of resistance from users of medicine.

Cameron Lawson

How come with every study that proves no link between cannabis and psychosis there are figures and factual evidence to support it, but with the converse, all that is given is "based on scientific research". Where are the figures? Where is the evidence?

Dan Ford

The two previous commentators have given a good account of how fears of Cannabis causing psychosis are blown out of all proportion. Having read the Keele report I know that Cannabis is many times LESS likely to cause it than alcohol.
However even IF (and it's a very big "IF") some of the more recently developed strains of Cannabis were causing this problem, those strains came about under the regime of prohibition! Prohibition does harm. It does no good whatsoever.

Danny

Five joints per day is a large amount to consume. To say smoking that many would give you issues is to firstly not understand how much that actually is, and to secondly fail to equate this with an amount of something you would entertain, such as alcohol or sugar.

If you were to drink 5 litre of vodka per day, you'd probably die early and painfully. And if you were to consume 10kg of sugar per day an even worse fate would greet you. There certainly wouldn't be merely an as-yet-unfounded suggestion of 'increased likelihood' of something happening.

So without even debating the dangers of a non-toxic plant, or the ethos of living in a free society, we can see that this article doesn't cover balancing out dangers with hard facts and comparisons. There are no peer-reviewed studies which support this level of scaremongering. Cannabis is a relatively safe plant, and we should focus on controlling the quality and education around its use. We know very obvious groups who shouldn't take it, and that's the sort of safeguarding that's needed here - not prison sentences and criminal records.

Steven

"Can Cannabis Cause Schizophrenia?" Why yes, of course! That's almost like asking; "Can eating cakes make you fat?" Yes it can, in some individuals, now what?

Lee

What seems to be happening here, in my own personal opinion, is those unwilling to accept that their biased opinions which have served them well in the past are now being quite rightly brought under scrutiny, and inevitably the outcome of which will be a change in the way we handle drugs for the better.

That is unless the government wish to continue burying their cowardly heads in the sand allowing criminals to prosper and deluded, paranoid, sensationalism spreading articles such as this research lacking drivel to be passed as fact.

I don't think it mere coincidence that those who make a career from so called cannabis psychosis and its prohibition are those who are firmly against changing laws and attitudes towards drugs. Why should they want to protect peoples welfare when there is large amounts of money to be made.

And to responded to the allegation that myself and those who also oppose these ridiculous pieces are part of a cult I would actually agree. We are the cult who use our own eyes to gather information and fact based evidence from scientific studies and bodies made up of well respected and learned individuals who question the current status quo. We are part of a new generation who have access to vast amounts of information and are able to form our own opinions rather than have them forced down our throats by self serving journalists trying to pave a career by stirring the s**t to send the masses into a frenzy of paranoia, provoking them to eat up more of the same filth on a daily basis in the hope you might actually feed them some answers. If there is one thing that society at large has realised in recent times is that the media is not interested in the truth, they are interested in selling papers.

How about you do the honourable thing for once and actually back the idea that prohibition has failed miserably and that change is inevitable. Whilst you resist you hold back progress and help harm society. Very shameful of you indeed.

wolfemurray

My intention in writing that article for the Huffington Post was simply to point out that there are risks involved with cannabis. As one commentator (Alex) said you only have to speak to psychiatrists or visit closed wards in mental hospitals to see the effect that cannabis can have on some people.

I didn't get into the de-criminalisation debate.

Chris

I've been using cannabis for years and so have most of my friends, none of us have schizophrenia; strange that innit!

Dragon83uk

There's a couple of points in this article which I think need expanding.
Firstly, and most importantly, is this suggested link between cannabis and psychosis. The reality is that THC is a psychoactive compound. To say that there is zero risk to absolutely anyone's mental health is, of course, completely short sighted. However the other part of that reality is to accept that, despite a huge growth in the amount of users of cannabis, rates of schizophrenia are either stable or declining. What this has to mean is that cannabis usage is causing, at most, a negligible effect on the nations mental health. To continue a system which causes huge negative effects on all, including those few unlucky souls, is completely preposterous. If not then please, explain to us all, how does a criminal record assist in the recovery of mental illness?

I must commend this site for pointing out one important factor though. One that is often misrepresented on this issue in the public forum. That being that psychoses are complicated things and one must already be predisposed to psychosis for cannabis use to be an issue. It is exactly this point that makes keeping cannabis illegal on the grounds of psychosis equatable to banning peanuts for the risk of anaphylaxis.
I personally feel that the best way to be dealing with mental well being is to finally bring it completely from the realms of "taboo" into the realms of the "normal". The fact that you guys are supporting a system that actively discourages this with such damaging effect is unsurprisingly strange from this perspective.

The second point I need to mention is a major failure of this article. Which is to repeat the nonsense argument that cannabis with a THC content of up to 18% is something new or fancy. Between the 60's and 90's hash was rife and easily could of had equal if not greater THC content. If modern forms of intensely farmed cannabis are really causing problems it's much more likely to due to lower amounts of anti-psychotic CBD's. Something which could only be effectively controlled by a system of regulation.

Unfortunately, given the claim in the comments that Peter Hitchens has a "good piece" anywhere, I doubt any of what I have said will matter. Like the mythical ostrich, heads will continue to be buried in sand. Never to see the tide rolling in.

Alexander

My doctor has prescribed me cannabis a couple of years ago. At first i was surprised because how can smoking help asthma. But the results where astonishing.
I am now a frequent user and even growing my own medicinal white widow.
I think cannabis has been helping a lot of people over the last hundreds of years.
People who have a predisposition for psychosis should maybe not smoke cannabis... but probably not drink also.

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